The invention discloses a preparation method of 17[alpha]-
hydroxyprogesterone, wherein the preparation method comprises the steps: refining: step 1, dissolving 1 W of a crude product into a
mixed solution of 4-5 V
dichloromethane and 6-8 V
ethanol, and heating to dissolve the crude product; step 2, weighing
activated carbon exceeding a preset amount, then putting the
activated carbon into a
drying device for
drying, controlling the
drying temperature to be 60-85 DEG C, and controlling the
drying time to be 10-15 minutes; and step 3, taking out the
activated carbon dried in the step 2, and then placing the activated carbon in a
grinding device for fine
grinding. According to the scheme, activated carbon in the refining process in an original scheme is finely processed and then added, so that the
reaction rate is effectively increased, the time of
reflux decoloration is shortened, large-scale production and
processing are facilitated, and the production cost is further reduced.