Preparation method of 17[alpha]-hydroxyprogesterone

[0023] In this embodiment, a 17α-hydroxy progesterone preparation method is proposed, including the following steps:

[0024] refined:

[0025] Step 1: The crude product 1 W is dissolved in 4 to 5 V dichloromethane and 6 to 8V ethanol mixed, heat it to dissolve;

[0026] Step 2: The activated carbon is performed extends over the predetermined amount, which is then placed in the drying apparatus for drying, and the drying temperature is controlled at 60 to 85 ° C, the drying time is controlled at 10-15 min;

[0027] Step 3: Remove the activated carbon after drying in step 2, then placed in the abrasive device for fine grinding;

[0028] Step 4: Collect and screen the active carbon ash refined in step 3, and perform a precision weighing, screen 0.05W.

[0029] Step 5: The filtered active carbon ash, refluxed 0.3 hours, concentrated from about 90% of the solvent, cooling 10 ° C to filter, dry below 70 ° C, product grade 17a-hydroxy progesterone, obtained product HPLC detection conten...

[0035] In this embodiment, a 17α-hydroxy progesterone preparation method is proposed, including the following steps:

[0036] refined:

[0037] Step 1: The crude product 1 W is dissolved in 4 to 5 V dichloromethane and 6 to 8V ethanol mixed, heat it to dissolve;

[0038] Step 2: The activated carbon is performed extends over the predetermined amount, which is then placed in the drying apparatus for drying, and the drying temperature is controlled at 60 to 85 ° C, the drying time is controlled at 10-15 min;

[0039] Step 3: Remove the activated carbon after drying in step 2, then placed in the abrasive device for fine grinding;

[0040] Step 4: Collect and screen the active carbon ash refined in step 3, and perform a precision weighing, screen 0.05W.

[0041] Step 5: The filtered active carbon ash, refluxed 0.4 hours, concentrated from about 90% of the solvent, cooling below 10 ° C to filter, dry below 70 ° C, product grade 17a-hydroxy progesterone, obtained product HPLC detection ...

[0047] In this embodiment, a 17α-hydroxy progesterone preparation method is proposed, including the following steps:

[0048] refined:

[0049] Step 1: The crude product 1 W is dissolved in 4 to 5 V dichloromethane and 6 to 8V ethanol mixed, heat it to dissolve;

[0050] Step 2: The activated carbon is performed extends over the predetermined amount, which is then placed in the drying apparatus for drying, and the drying temperature is controlled at 60 to 85 ° C, the drying time is controlled at 10-15 min;

[0051] Step 3: Remove the activated carbon after drying in step 2, then placed in the abrasive device for fine grinding;

[0052] Step 4: Collect and screen the active carbon ash refined in step 3, and perform a precision weighing, screen 0.05W.

[0053] Step 5: The filtered active carbon ash, refluxed 0.5 hours, concentrated from about 90% of the solvent, cooling 10 ° C to filtration, 70 ° C, drying, product grade 17a-hydroxypertone, obtained product HPLC detection content> 9...