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Method for diagnosing and/or evaluating retinal disease

a retinal disease and retinal disease technology, applied in the field of retinal diseases, can solve the problems of reduced vision, loss of eyesight, and the actual effectiveness of isopropyl unoprostone has not yet been evaluated, and achieve the effect of improving the quality of life and the visual cell (rod cells)

Inactive Publication Date: 2012-04-12
R TECH UENO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention relates to a method for treating retinal diseases using a fatty acid derivative. The invention also includes a pharmaceutical composition containing the fatty acid derivative for treating retinal diseases. The invention further provides a program and system for evaluating and diagnosing retinal diseases based on retinal sensitivity and visual-related quality of life. The invention also provides an ophthalmic composition for improving rod cell function, cone cell function, and vision-related quality of life in patients with retinal diseases. The invention also provides a method for improving vision-related quality of life in patients with retinal diseases."

Problems solved by technology

The disease is an intractable disease which starts from night blindness as clinical symptoms and decreases retinal sensitivity to cause visual field constriction and reduced vision, leading to loss of eyesight.
In addition, no clinical study include patients treated with placebo ophthalmic solution and therefore, the actual effectiveness of isopropyl unoprostone has not yet evaluated.
However, generally, it is considered that a drug hardly migrates to the eyeground tissue such as retina in instillation and, if the drug migrates, it is very hard to maintain the concentration of the drug in the tissue.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

formulation example 1

[0229]The respective components were dissolved in purified water so as to adjust to each w / v % shown below, and the solution was aseptically filtered and then filled into a sterilized low density polyethylene container to obtain an ophthalmic solution (one drop volume: approximately 35 μL).

 0.15%isopropyl unoprostone(UF-021) 1.0%Polyoxyethylene sorbitan monooleate 1.0%Mannitol 1.9%Glycerin 0.05%Sodium edetate0.003%Benzalkonium chloride

formulation example 2

[0230]Using the solution prepared by dissolving the respective components in purified water so as to adjust to each w / v % shown below and aseptically filtrating, a sterile unit dose (one-day disposable type) ophthalmic solution was obtained by a Blow Fill Seal system.

0.18%isopropyl unoprostone0.70%Polyoxyethylene sorbitan monooleate0.30%Polyoxyl 10 oleyl ether 4.7% Mannitol0.01%Sodium edetate

formulation example 3

[0231]Using the solution prepared by dissolving the respective components in purified water so as to adjust to each w / v % shown below and aseptically filtrating, a sterile unit dose (single unit dose type) ophthalmic solution was obtained by a Blow Fill Seal system.

0.24%isopropyl unoprostone0.95%Polyoxyethylene sorbitan monooleate0.42%Polyoxyl 10 oleyl ether4.7%Mannitol0.01%Sodium edetate

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PUM

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Abstract

The present application provides a method for diagnosing and / or evaluating the presence or absence, severity or degree of the improvement of a retinal disease in a subject, which comprises determining and / or evaluating circulatory parameters, retinal function, retina morphology and / or visual relating quality of life (QOL).

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation in part of U.S. application Ser. No. 13 / 084,927 that claims priorities to U.S. Provisional Patent Application No. 61 / 323,338 filed Apr. 12, 2010, U.S. Provisional Patent Application No. 61 / 323,342 filed Apr. 12, 2010, U.S. Provisional Patent Application No. 61 / 326,811 filed Apr. 22, 2010, U.S. Provisional Patent Application No. 61 / 362,945 filed Jul. 9, 2010 and U.S. Provisional Patent Application No. 61 / 408,237 filed Oct. 29, 2010, the contents of each of which are herein incorporated by reference in their entirety.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention relates to a method for treating retinal diseases using a fatty acid derivative, and the use of an ophthalmic composition comprising the fatty acid derivative. The present invention also relates to a method for improving a visual cell (rod cells and cone cells) function or vision-related quality of life (QOL)...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K49/00G06F19/00A61B3/00A61B3/024A61K38/06A61P27/02
CPCA61K31/5575A61P27/02
Inventor MASHIMA, YUKIHIKOUENO, RYUJI
Owner R TECH UENO
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