Preparation methods of sulbenicillin sodium and injection thereof

By simplifying the process flow and controlling the reaction conditions, the problems of complex reactions and numerous by-products in the preparation of sulfonicillin sodium are solved, an efficient and raw material-saving preparation method is achieved, the purity and yield of the product are improved, and it is suitable for industrial promotion.

CN101805356AInactive Publication Date: 2010-08-18HUNAN ERKANG XIANGYAO PHARMA
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Patent Information

Application Number
CN201010156636.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2010-04-27
Publication Date
2010-08-18
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

The existing preparation process of sulfenicillin sodium has complex reactions, many by-products, low yields, serious waste of raw materials, and lacks simple and efficient process methods.

Method used

Adopting a simplified process flow, including sulfonation, hydrolysis, crystallization, ion exchange, acylation, condensation and extraction, etc., using raw materials such as dichloroethane, thionyl chloride, butyl acetate, and controlling the temperature and pH value, Reduce side reactions and improve product purity and yield.

Benefits of technology

The simplicity of the process flow is achieved, reaction impurities are reduced, the purity and yield of sulfonicillin sodium are improved, the economical use of raw materials is ensured, and the method is suitable for industrial production.

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Abstract

The invention discloses a preparation method of sulbenicillin sodium, which comprises the following steps of: sulfonating, hydrolyzing, crystallizing, ion-exchanging, acidylating, condensing, extracting and salifying to obtain sulbenicillin sodium. The method has the advantages of simple technological steps, fewer reaction impurities and high product purity, and the yield is higher than 50%. Meanwhile, the invention also relates to a preparation method of a sulbenicillin sodium injection.
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